National Institute of Health
Contract HHS-N-263-2007-00053-C
The Effects of Intracochlear Electrical Stimulation on Neural Survival and Connectivity

Hartley, D.E., Vongpaisal, T., Xu, J., Shepherd, R.K., King, A.J. and Isaiah, A. 2010. Bilateral cochlear implantation in the ferret: A novel animal model for behavioral studies. J Neurosci Methods: 190, 214-28. [Abstract]

Halpern, M. and Fallon, J. 2010. Current waveforms for neural stimulation charge delivery with reduced maximum electrode voltage. IEEE Transactions on Biomedical Engineering: in press. [Abstract]

Hanifa, S., Scott, H.S., Crewther, P., Guipponi, M. and Tan, J. 2010. Thyroxine treatments do not correct inner ear defects in tmprss1 mutant mice. NeuroReport. in press. [Abstract]

Wise, A.K., Hume, C.R., Flynn, B.O., Jeelall, Y.S., Suhr, C.L., Sgro, B.E., O'Leary, S.J., Shepherd, R.K. and Richardson, R.T. 2010. Effects of localized neurotrophin gene expression on spiral ganglion neuron resprouting in the deafened cochlea. Molecular Therapy. in press [Abstract]

Ryugo, D.K., Baker, C.A., Montey, K.L., Chang, L.Y., Coco, A., Fallon, J.B. and Shepherd, R.K. 2010. Synaptic plasticity after chemical deafening and electrical stimulation of the auditory nerve in cats. Journal of Comparative Neurology: 518, 1046-63. [Abstract]

Fallon, J.B., Shepherd, R.K., Brown, M. and Dexter, R.F.I. 2009. Effects of neonatal partial deafness and chronic intracochlear electrical stimulation on auditory and electrical response characteristics in primary auditory cortex. Hearing Research: 257, 93-105. [Abstract]

Fallon, J.B., Irvine, D.R.F. and Shepherd, R.K. 2009. Neural prostheses and brain plasticity. Journal of Neural Engineering: 6, 65008. [Abstract]

Richardson, R.T., Wise, A.K., Thompson, B.C., Flynn, B.O., Atkinson, P.J., Fretwell, N.J., Fallon, J.B., Wallace, G.G., Shepherd, R.K., Clark, G.M. and O'Leary, S.J. 2009. Polypyrrole-coated electrodes for the delivery of charge and neurotrophins to cochlear neurons. Biomaterials: 30, 2614-2624. [Abstract]

Coleman, B., Rickard, N.A., de Silva, M.G. and Shepherd, R.K. 2009. A protocol for cryoembedding the adult guinea pig cochlea for fluorescence immunohistology. Journal of Neuroscience Methods: 176, 144-51. [Abstract]

Fallon, J.B., Irvine, D.R. and Shepherd, R.K. 2009. Cochlear implant use following neonatal deafness influences the cochleotopic organization of the primary auditory cortex in cats. Journal of Comparative Neurology: 512, 101-114. [Abstract]

This article was also reported in New Scientist.

Shepherd, R.K., Epp, S.B. and Coco, A. 2008. Neurotrophins and electrical stimulation for protection and repair of spiral ganglion neurons following sensorineural hearing loss. Hearing Research : 242,100-9. [Abstract]

Pettingill, L.N., Minter, R.L. and Shepherd, R.K. 2008. Schwann cells genetically modified to express neurotrophins promote spiral ganglion neuron survival in vitro. Neuroscience: 152, 821-828. [Abstract]

Glynn, F., Tan, J., Wang, Y., Caruso, F. and Shepherd, R. A novel therapeutic approach encapsulating brain-derived neurotrophic factor in nanoporous protein particles: Implications for clinical neurosciences. Proceedings of the Sydney 2010 International Medicine Conference. Sydney, Australia, 30 Jun – 2 Jul 2010. [Abstract]

Shepherd, R.K. Medical bionics: Applications in neurological diseases. Proceedings of the 2nd Asia-Pacific Symposium on Nanobionics. University of Wollongong, NSW, 9-11 June 2010.

Shepherd, R., Irvine, D., Pujol, R., Richardson, R., Pettingill, L., Wise, A. and Fallon, J. Auditory deprivation and cochlear implants: Pathological, atrophic and plastic changes in the auditory system. Proceedings of the 11th International Conference on Cochlear Implants and other Auditory Implantable Technologies. Stockholm, Sweden, 29 June- 3 July 2010. [Abstract]

Perry, D.W.J., Fallon, J.B., McDermott, H. and Shepherd, R.K. Development of a novel rodent model for examining central auditory plasticity with cochlear implant use. Proceedings of the Thirthy-Third Annual Midwinter Research Meeting of the Association for Research in Otolaryngology. Anaheim, CA, February 6 - 10 2010. [Abstract]

Landry, T.G., Wise, A.K., Fallon, J.B. and Shepherd, R.K. Chronic neurotrophin infusion and electrical stimulation in the deaf cochlea: Implications for cochlear implant spatial selectivity. Proceedings of the Thirthy-Third Annual Midwinter Research Meeting of the Association for Research in Otolaryngology. Anaheim, CA, February 6 - 10 2010. [Abstract]

Fallon, J.B., Irvine, D.R.F., Evans, A.J., Landry, T.G. and Shepherd, R.K. Effects of long-term deafness and delayed chronic intracochlear electrical stimulation on the primary auditory cortex. Proceedings of the Thirthy-Third Annual Midwinter Research Meeting of the Association for Research in Otolaryngology. Anaheim, CA, February 6 - 10 2010. [Abstract]

Wise, A.K., Fallon, J.B., Evans, A.J., Andrew, J., Pettingill, L.N., Geaney, M.S. and Shepherd, R.K. Protection of spiral ganglion neurons with neurotrophins and chronic electrical stimulation. Proceedings of the ANS/AuPS 2010 Joint Meeting. Sydney, Australia, 31 January-3 February 2010. [Abstract]

Landry, T.G., Wise, A.K., Fallon, J.B. and Shepherd, R.K. Chronic neurotrophin infusion and electrical stimulation in the deaf cochlea: Implications for cochlear implant spatial selectivity. Proceedings of the ANS/AuPS 2010 Joint Meeting. Sydney, Australia, 31 January-3 February 2010. [Abstract]

Fallon, J.B., Irvine, D.R.F., Evans, A.J., Landry, T.G. and Shepherd, R.K. Effects of long-term deafness and delayed chronic intracochlear electrical stimulation on the primary auditory cortex. Proceedings of the ANS/AuPS 2010 Joint Meeting. Sydney, Australia, 31 January-3 February 2010. [Abstract]

Wise, A.K., Fallon, J.B., O'Leary, S.J., Sly, D.J. and Shepherd, R.K. The response of auditory neurons to multichannel electrical stimulation in the deaf and chronically stimulated cochlea. Proceedings of Inner Ear Biology. Utrecht, Netherlands, 12 - 15 September 2009. [Abstract]

Wise, A.K., Fallon, J.B., O'Leary, S.J., Sly, D.J. and Shepherd, R.K. The response of auditory neurons to multichannel electrical stimulation in the deaf and chronically stimulated cochlea. Proceedings of the Conference on Implantable Auditory Prostheses. Lake Tahoe, CA, USA, July 12 -17 2009. [Abstract]

Wise, A.K., Fallon, J.B., Evans, A.J., Andrew, J., Pettingill, L.N., Geaney, M. and Shepherd, R.K. Protection of spiral ganglion neurons with neurotrophins and chronic electrical stimulation. Proceedings of the Conference on Implantable Auditory Prostheses. Lake Tahoe, CA, USA, July 12 -17 2009. [Abstract]

Richardson, R., Wise, A., Hume, C., Flynn, B., Jeelall, Y., Suhr, C., Sgro, B., O’Leary, S. and Shepherd, R. Effects of localized neurotrophin gene therapy on auditory neurons after hearing loss. Proceedings of the Conference on Implantable Auditory Prostheses. Lake Tahoe, CA, USA, July 12 -17 2009. [Abstract]

Nayagam, B.A., Edge, A.S., Ryugo, D.K., Shepherd, R.K. and Dottori, M. The potential of stem cells for auditory neuron generation and replacement in the deaf cochlea. Proceedings of the Conference on Implantable Auditory Prostheses. Lake Tahoe, CA, USA, July 12 -17 2009. [Abstract]

Heffer, L.F., White, M.W., Fallon, J.B., Sly, D.J. and O'Leary, S.J. Modeling the temporal response properties of auditory nerve fibers to pulsatile electrical stimulation. Proceedings of the Conference on Implantable Auditory Prostheses. Lake Tahoe, CA, USA, July 12 -17 2009. [Abstract]

Hartley, D.E.H., Isaiah, A., Vongpaisal, T., Shepherd, R.K. and King, A.J. Spatial hearing in ferrets with cochlear implants. Proceedings of the Conference on Implantable Auditory Prostheses. Lake Tahoe, CA, USA, July 12 -17 2009. [Abstract]

Fallon, J.B., Shepherd, R.K. and Irvine, D.R.F. Effects of partial deafness and chronic intracochlear electrical stimulation on auditory and electrical response characteristics in primary auditory cortex. Proceedings of the Conference on Implantable Auditory Prostheses. Lake Tahoe, CA, USA, July 12 -17 2009. [Abstract]

Fallon, J.B., Shepherd, R.K. and Irvine, D.R.F. Effects of long-term deafness and chronic intracochlear electrical stimulation on the primary auditory cortex. Proceedings of the Conference on Implantable Auditory Prostheses. Lake Tahoe, CA, USA, July 12 -17 2009. [Abstract]

Celik, S., Ruhland, J., Gubbels, S., Irwin, C., Fallon, J.B., Shepherd, R.K., Litovsky, R. and Yin, T. Bilateral cochlear implants in cats: Preliminary observations on sound localization abilities. Proceedings of the Conference on Implantable Auditory Prostheses. Lake Tahoe, CA, USA, July 12 -17 2009. [Abstract]

Wise, A.K. The effects of deafness and chronic electrical stimulation on the temporal and spatial characteristics of auditory neurons. Proceedings of the 6th Australasian Auditory Neuroscience Workshop. Canberra, ACT, Australia, 31 January 2009.

Fallon, J.B., Donley, L., Evans, A., Giummarra, M., Coco, A. and Shepherd, R.K. Histopathologic effects of chronic cochlear implant use. Proceedings of the Australia Neuroscience Society Inc., 29th Annual Meeting. Canberra, ACT, Australia, 27-30 January 2009. [Abstract]

Wise, A.K., Fallon, J.B., O'Leary, S.J., Sly, D.J. and Shepherd, R.K. The effects of deafness and chronic electrical stimulation on the spatial and temporal characteristics of auditory neurons. Proceedings of the Australia Neuroscience Society Inc., 29th Annual Meeting. Canberra, ACT, Australia, 27-30 January 2009. [Abstract]

Landry, T.G., Fallon, J.B., Wise, A.K. and Shepherd, R.K. Effects of exogenous neurotrophins in the deaf stimulated cochlea. Proceedings of the Medical Bionics - a new paradigm for human health. Lorne, Victoria, Australia, 16-19 November 2008. [Abstract] Awarded MiniFab Best Poster Prize.

Perry, D.W.J., Fallon, J.B., Grayden, D.B., Millard, R.E. and Shepherd, R.K. A fully implantable two-channel cochlear stimulator for rats. Proceedings of the Medical Bionics - a new paradigm for human health. Lorne, Victoria, Australia, 16-19 November 2008. [Abstract]

Glynn, F., Tan, J., Wang, Y., Caruso, F. and Shepherd, R.K. A novel therapeutic approach encapsulating brain-derived neurotrophic factor in nanoporous particles for treating sensorineural hearing loss. Proceedings of the Medical Bionics - a new paradigm for human health. Lorne, Victoria, Australia, 16-19 November 2008. [Abstract]

Wise, A.K., Fallon, J.B., O'Leary, S.J., Sly, D.J. and Shepherd, R.K. Spatial and temporal characteristic of auditory neurons in response to deafness and chronic electrical stimulation. Proceedings of the Medical Bionics - a new paradigm for human health. Lorne, Victoria, Australia, 16-19 November 2008. [Abstract]

Millard, R.E., Fallon, J.B., Coco, A. and Shepherd, R.K. Use of commercial cochlear implants for chronic stimulation of laboratory animals. Proceedings of the Medical Bionics - a new paradigm for human health. Lorne, Victoria, Australia, 16-19 November 2008. [Abstract]

Fallon, J.B., Irvine, D.R.F. and Shepherd, R.K. Sensory neural prostheses and brain plasticity. Proceedings of the Medical Bionics - a new paradigm for human health. Lorne, Victoria, Australia, 16-19 November 2008. [Abstract]

Fallon, J.B., Irvine, D.R.F. and Shepherd, R.K. Changes in the cochleotopic organization of primary auditory cortex resulting from chronic deafness and cochlear implantation. Proceedings of the 2nd Queensland Brain Institute, Brain Plasticity Symposium. Brisbane, Queensland, Australia, 9-12 September 2008. [Abstract] [Poster]

Hartley, D.E.H., Isaiah, A., Schnupp, J.W.H., Dahmen, J.C., Fallon, J.B., Shepherd, R.K. and King, A.J. Potential benefits of half-wave rectified stimuli to individuals with bilateral cochlear implants. Proceedings of the British Society of Audiology Meeting. University of Nottingham, 9-11 September 2008. [Abstract]

Fallon, J.B., Irvine, D.R.F. and Shepherd, R.K. Changes in the cochleotopic organization of primary auditory cortex resulting from chronic deafness and cochlear implantation. Proceedings of the Thirty-Eight Neural Interfaces Conference. Cleveland, Ohio, USA, 16-18 June 2008. [Abstract] [Poster]

Fallon, J.B., Wise, A.K. and Shepherd, R.K. Factors affecting neural response telemetry recordings in the chronically stimulated cat. Proceedings of the Thirty-First Annual Midwinter Research Meeting of the Association for Research in Otolaryngology. Phoenix, Arizona, USA, 16-21 February 2008. [Abstract]

Hartley, D., Isaiah, A., Schnupp, J., Dahmen, J., Fallon, J.B., Shepherd, R.K. and King, A. Sensitivity to interaural time delays in the auditory cortex of ferrets: Investigating potential benefits of half-wave rectified stimuli to individuals with bilateral cochlear implants. Proceedings of the Thirty-First Annual Midwinter Research Meeting of the Association for Research in Otolaryngology. Phoenix, Arizona, USA, 16-21 February 2008. [Abstract]

Shepherd, R.K., Coco, A., Andrew, J., Wise, A.K. and Pettingill, L.N. Delivery strategies for neurotrophin delivery into the inner ear for SGN protection following deafness. Proceedings of the Thirty-First Annual Midwinter Research Meeting of the Association for Research in Otolaryngology. Phoenix, Arizona, USA, 16-21 February 2008. [Abstract]

Tan, J., Widjaja, S., Xu, J. and Shepherd, R.K. Cochlear implants stimulate activity-dependent CREB pathway in the deaf auditory cortex: Implications for molecular plasticity induced by neural prosthetic devices. Proceedings of the Thirty-First Annual Midwinter Research Meeting of the Association for Research in Otolaryngology. Phoenix, Arizona, USA, 16-21 February 2008. [Abstract] [Poster]

Heffer, L.F. and Fallon, J.B. A novel stimulus artifact removal technique for high-rate electrical stimulation. Proceedings of the Australia Neuroscience Society Inc., 28th Annual Meeting. Hobart, Tasmania, Australia, 27-30 January 2008. [Abstract][Poster]

Perry, D.W.J., Fallon, J.B., Grayden, D.B., Millard, R.E. and Shepherd, R.K. Research cochlear implant for small laboratory animals. Proceedings of the Australia Neuroscience Society Inc., 28th Annual Meeting. Hobart, Tasmania, Australia, 27-30 January 2008. [Abstract]

Shepherd, R.K., Epp, S.B. and Coco, A. Electrical stimulation maintains spiral ganglion neurons following removal of exogenous neurotrophins. Proceedings of the Australia Neuroscience Society Inc., 28th Annual Meeting. Hobart, Tasmania, Australia, 27-30 January 2008. [Abstract]

Wimberley, C.J., Fallon, J.B., Irvine, D.R.F. and Shepherd, R.K. Cochleotopic organisation of the central auditory pathway in the neonatally deafened cat. Proceedings of the Australia Neuroscience Society Inc., 28th Annual Meeting. Hobart, Tasmania, Australia, 27-30 January 2008. [Abstract]

Wise, A.K., Fallon, J.B., Heasman, J.M. and Shepherd, R.K. Factors affecting neural response telemetry recordings in the chronically stimulated cat. Proceedings of the Australia Neuroscience Society Inc., 28th Annual Meeting. Hobart, Tasmania, Australia, 27-30 January 2008. [Abstract]

Heffer, L.F. and Fallon, J.B. A novel stimulus artifact removal technique for high-rate electrical stimulation. Proceedings of the 5th Australasian Auditory. Neuroscience Workshop Hobart, Australia, 31 January 2008.

Landry, T.G., Wise, A.K., Fallon, J.B. and Shepherd, R.K. Functional effects of exogenous neurotrophins in the deafened cochlea. Proceedings of the 5th Australasian Auditory Neuroscience Workshop. Hobart, Australia, 31 January 2008.

Perry, D.W.J., Fallon, J.B., Grayden, D.B., Millard, R. and Shepherd, R.K. Research cochlear implant for small laboratory animals. Proceedings of the 5th Australasian Auditory Neuroscience Workshop. Hobart, Australia.