Molecular analysis of synaptic plasticity changes in the auditory cortex
The main principle of the Bionic Ear involves electrical stimulation of auditory neurons in the brain so that input to the auditory system is reactivated. This strategy has successfully restored hearing to many patients with severe to profound hearing loss. The molecular mechanisms which drive these changes remain to be elucidated.
Our aim is to map the genes and molecular changes associated with deafness. This will enable us to design protective strategies such as gene therapy to prevent further hearing loss. Using diverse molecular techniques, we also seek to understand cellular and molecular pathologies in mutant mice exhibiting auditory deficits.
Funding
The Garnett Passe and Rodney Williams Memorial Foundation and US National Institutes of Health(HHS-N-263-2007-00053-C)
Effects of cochlear implants on plasticity genes in the brain